Chinese Journal of Organic Chemistry >
Synthetic Progress of Jiadifenolide
Received date: 2015-11-30
Revised date: 2015-12-29
Online published: 2016-01-07
Supported by
Project supported by the National Natural Science Foundations of China (Nos. 21142007, 21272194, 21572187, U1405228), the Fundamental Research Funds for the Central Universities (No. 20720160025) and the Program for Changjiang Scholars and Innovative Research Team in University.
Jiadifenolide, a new seco-prezizaane-type sesquiterpenoid, was isolated from Chinese unique medicine Illicium jiadifengpi. It contains a highly oxygenated cagelike architecture with seven contiguous stereocenters. It displays potent neurotrophic activity at very low concentration and is regarded as a promising lead compound for developing drugs for neurodegenerative diseases. This review summarizes the synthetic efforts towards jiadifenolide in the last five years.
Li Linbin , Shen Yang , Zhang Yandong . Synthetic Progress of Jiadifenolide[J]. Chinese Journal of Organic Chemistry, 2016 , 36(3) : 439 -446 . DOI: 10.6023/cjoc201511054
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