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Chinese Journal of Organic Chemistry >

2016 , Vol. 36 >Issue 5: 1122 - 1126

DOI: https://doi.org/10.6023/cjoc201512013

NOTE

Efficient Synthesis of Chloromethyl Methyl Ether and One-Pot Hydroxyl Protection

  • Zheng Dongqing ,
  • Cao Wei ,
  • Ma Haiyan ,
  • Ding Kai
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  • a. Laboratory of Organometallic, East China University of Science and Technology, Shanghai 200237;
    b. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received date: 2015-12-09

  Revised date: 2016-01-05

  Online published: 2016-01-15

Supported by

Project supported by the National Natural Science Foundation for Young Scientists of China (No. 20902098).

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Abstract

Chloromethyl methyl ether (MOMCl) is an important protecting agent in organic synthesis. An efficient synthesis of chloromethyl methyl ether is reported and a one-pot hydroxyl protection procedure is developed. The method features mild condition, short reaction time, high yield and simple operation.

Key words： chloromethyl methyl ether; hydroxyl protecting agent; one-pot

Cite this article

Zheng Dongqing , Cao Wei , Ma Haiyan , Ding Kai . Efficient Synthesis of Chloromethyl Methyl Ether and One-Pot Hydroxyl Protection[J]. Chinese Journal of Organic Chemistry, 2016 , 36(5) : 1122 -1126 . DOI: 10.6023/cjoc201512013

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