Chinese Journal of Organic Chemistry >
Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety
Received date: 2015-12-14
Revised date: 2016-01-07
Online published: 2016-02-02
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (Nos. 2011-SWYY-009, 2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (Nos. AS2014011, CP12013002).
In order to find novel cyanoacrylate lead compounds, 17 new cyanoacrylate compounds bearing fluoride methyl pyrazole moiety were synthesized by the method of active substructure combination. They were structurally confirmed by 1H NMR, 13C NMR and elemental analysis. The structures of compounds 7b, 7f, 7j and 7o were also tested through MS technique. Preliminary bioassay data showed that some of the target compounds displayed important anti-tumor activities.
Key words： fluoride methyl pyrazole; cyanoacrylate; synthesis; biological activity
Shi Yujun , Li Yang , Fang Yuan , Ye Linyu , Chen Jia , Dai Hong . Synthesis and Bioactivity of Novel Cyanoacrylate Derivatives Containing Fluoride Methyl Pyrazole Moiety[J]. Chinese Journal of Organic Chemistry, 2016 , 36(6) : 1431 -1437 . DOI: 10.6023/cjoc201512019
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