Chinese Journal of Organic Chemistry >
Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols
Received date: 2015-10-21
Revised date: 2015-12-15
Online published: 2016-02-01
Supported by
Project supported by the Open Project Program of Hubei Key Laboratory of Drug Synthesis and Optimization Jingchu University of Technology (Nos. OPP2015YB01, OPP2015ZD02), the Talents of High Level Scientific Research Foundation of Qingdao Agricultural University (Nos. 6631112323, 6631115015).
The electrophilic intermediate, vinylogous imine or vinylogous iminium, can be in situ generated from 3-indolyl- methanols under acidic conditions. With the aid of chiral catalysts, miscellaneous nucleophiles can attack these electrophilic intermediates to afford enantioenriched and biologically important 3-substituted indole derivatives. The recent advances of preparation of optically active indole derivatives from 3-indolylmethanols via asymmetric alkylation, asymmetric reduction and asymmetric rearrangement are summarized.
Zhu Shuai , Xu Lubin , Wang Liang , Xiao Jian . Recent Advances in Asymmetric Synthesis of Optically Active Indole Derivatives from 3-Indolylmethanols[J]. Chinese Journal of Organic Chemistry, 2016 , 36(6) : 1229 -1240 . DOI: 10.6023/cjoc201510024
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