Chinese Journal of Organic Chemistry >
Application of Ugi/De-Boc/Cyclization Strategy in the Synthesis of Nitrogen-Containing Heterocycles
Received date: 2015-11-03
Revised date: 2016-01-07
Online published: 2016-02-01
Supported by
Project supported by the National Natural Science Foundation of China (No. 30873140), the Program for Excellent Talents of Beijing City (No. 20071D0501600227) and the Beijing Municipal Commission of Education (No. KM201010028011).
Ugi/de-Boc/cyclization (UDC) strategy represents a “three-step, one-pot procedure”, employing the Ugi multi-component reaction utilizing one bi-functional group substrates with N-Boc-protected amino, followed by Boc-deprotection and cyclization to synthesize nitrogen-containing heterocycles. This strategy has the characteristics of rapid, efficiency, economy and structural diversity, which can be used to build libraries of complex nitrogen-containing heterocycles and has drawn much attention recently. In this paper, the research progress of UDC strategy in the synthesis of five-, six- and seven-mem- bered heterocycles and natural products were summarized.
Zhang Zhaorui , Zheng Xiaolin , Guo Changbin . Application of Ugi/De-Boc/Cyclization Strategy in the Synthesis of Nitrogen-Containing Heterocycles[J]. Chinese Journal of Organic Chemistry, 2016 , 36(6) : 1241 -1265 . DOI: 10.6023/cjoc201511004
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