Chinese Journal of Organic Chemistry >
Diacetoxyiodobenzene Promoted Chlorination of Silyl Enol Ether of Aryl Ketones
Received date: 2015-11-19
Revised date: 2015-12-30
Online published: 2016-02-01
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21362033, 21502154).
A series of α-chloroketones were obtained from silyl enol ethers of aryl ketones using trimethylchlorosilane as chlorine source and diacetoxyiodobenzene as promoter. The reaction occurs under mild condition yielding the product in moderate to good yields, and has the potential possibility for the synthesis of α-bromoketone by using trimethyl bromosilane as bromine source.
Chen Xiaowei , Chong Siying , Du Ganggang , Huang Danfeng , Wang Kehu , Su Yingpeng , Hu Yulai . Diacetoxyiodobenzene Promoted Chlorination of Silyl Enol Ether of Aryl Ketones[J]. Chinese Journal of Organic Chemistry, 2016 , 36(5) : 1028 -1033 . DOI: 10.6023/cjoc201511041
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