Chinese Journal of Organic Chemistry >
A Novel Synthetic Route for Berberine Chloride
Received date: 2015-11-16
Revised date: 2016-01-02
Online published: 2016-02-18
Supported by
Project supported by the Fundamental Research Funds for the Central Universities, Southwest University for Nationalities (No. 2014NZYQN21), and the Research Projects Sichuan Provincial Department of Education (No. 15ZB0487).
Berberine chloride was synthesized starting from pyrocatechol in overall 13.6% yield. The key steps include a Hofmann rearrangement, chloromethylation, nucleophilic substitution, hydrolysis, decarboxylation, and cyclization. All of intermediates were determined by 1H NMR, 13C NMR, MS techniques.
Chen Cheng , Luo Zhuoma , Yang Hongjun , Feng Yuchuan . A Novel Synthetic Route for Berberine Chloride[J]. Chinese Journal of Organic Chemistry, 2016 , 36(6) : 1426 -1430 . DOI: 10.6023/cjoc201511028
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