Chinese Journal of Organic Chemistry >
Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one
Received date: 2015-12-05
Revised date: 2016-01-28
Online published: 2016-02-18
Supported by
Project supported by the Natural Science Basic Research Plan in Shaanxi Province (No. 2014JQ2064) and the Foundation for Young Scholars of Shaanxi University of Science & Technology (No. BJ12-26).
In order to develop new potent anti-phytopathogenic fungi drugs, a series of 2-sulfanylidene-2,3-dihydroquinazo- line-4(1H)-ones were synthesized under ultrasonic irradiation. Structures of the compounds were characterized by IR, 1H NMR, 13C NMR and MS. All compounds were investigated for anti-phytopathogenic fungi activity via the method of minimum inhibitory concentrations. The majority of compounds exhibited a good inhibitory activity to Alternaria brassicae and Colletotrichum gloeosporioides. The minimum inhibitory concentrations of compounds 3a, 3b, 3g and 3h were 16 μg/mL, which showed significant inhibitory activity to Alternaria brassicae compared with that of the positive control drug ketoconazole.
Zhang Jin , Cheng Pei , Ma Yangmin , Liu Jia , Miao Zhi , Fan Chao . Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one[J]. Chinese Journal of Organic Chemistry, 2016 , 36(6) : 1368 -1374 . DOI: 10.6023/cjoc201512008
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