Chinese Journal of Organic Chemistry >
Efficient and Green Synthesis of 5-[(Indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives in the Melt
Received date: 2016-01-10
Revised date: 2016-02-01
Online published: 2016-02-24
Supported by
Project supported by the National Natural Science Foundation of China (No. 21403100), and the Doctoral Scientific Research Foundation of Liaoning Province (No. 20141100).
An efficient melting method for the synthesis of β-indole derivatives via Yonemitsu reaction was developed successfully using aldehyde, indole and Meldrum's acid as the starting materials and 50 μL water as green promoter without other solvent. A series of 5-[(indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized in 55%~94% yields. The remarkable advantages of this reaction were mild reaction condition, easy operation, tolerant the substrates with diverse functional groups and environment-friendly.
Lü Chengwei, Liu Yanhang, Zhou Xiaoxia . Efficient and Green Synthesis of 5-[(Indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives in the Melt[J]. Chinese Journal of Organic Chemistry, 2016 , 36(6) : 1407 -1411 . DOI: 10.6023/cjoc201601010
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