Chinese Journal of Organic Chemistry >
Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety
Received date: 2016-01-11
Revised date: 2016-02-22
Online published: 2016-03-11
Supported by
Project supported by the “111” Project of Ministry of Education of China (No. B06005), and the State Key Laboratory of Elemento-organic Chemistry and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).
A series of novel coumarin derivatives containing sulfinic esters or sulfonamide were designed and synthesized. Their structures were characterized by 1H NMR, 13C NMR and elemental analysis. The preliminary bioassays indicated that several target compounds exhibited good in vitro antitumor activities on A549 (up to 67.82%), Bel7402 (up to 58.47%) and HCT-8 (up to 74.80%) at 5.0 mg/L and moderate antifungal activities on Physalospora piricola (up to 82.0 %) at 50 mg/L. The structure-activity relationship of these target compounds was discussed accordingly.
Key words： coumarin; sulfinic esters; sulfinamide; anticancer activity; antifungal activity
Liu Ming , Liu Yang , Liu Ailin , Zhang Dongkai , Chen Minggui , Wu Changchun , Hua Xuewen , Zhou Sha , Li Zhengming . Synthesis and Bioactivities of Novel Coumarin Derivatives Containing Sulfinic Esters or Sulfinamide Moiety[J]. Chinese Journal of Organic Chemistry, 2016 , 36(7) : 1653 -1661 . DOI: 10.6023/cjoc201601011
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