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Chinese Journal of Organic Chemistry >

2016 , Vol. 36 >Issue 7: 1681 - 1685

DOI: https://doi.org/10.6023/cjoc201601034

Notes

Tetra-butyl Ammonium Iodide-Catalyzed Oxidative Dehydrogenation for the Selective Synthesis of Z-β-Acylamino Enones

  • Zhao Yuying ,
  • Wang Erbing ,
  • Wang Yingli
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  • a. Institute of Chemical and Biological Technology, Taiyuan University of Science and Technology, Taiyuan 030021;
    b. Department of Traditional Chinese Pharmacology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024

Received date: 2016-01-27

  Revised date: 2016-02-26

  Online published: 2016-03-18

Supported by

Project supported by the Science and Technology Key Project of Shanxi Province (No. 20130313015-2).

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Abstract

A tetra-butyl ammonium iodide (TBAI)-catalyzed oxidative dehydrogenation of β-acylamino ketones for the synthesis of Z-β-acylamino enones has been developed. The present method has some distinct advantages such as mild conditions, high selectivity, readily available starting materials, and broad substrate scope. This method is also the first example of oxidative dehydrogenation with the use of TBAI/TBHP (tert-butyl hydroperoxide) oxidation system.

Key words： iodide; catalytic dehydrogenation; β-acylamino enones; stereoselectivity

Cite this article

Zhao Yuying , Wang Erbing , Wang Yingli . Tetra-butyl Ammonium Iodide-Catalyzed Oxidative Dehydrogenation for the Selective Synthesis of Z-β-Acylamino Enones[J]. Chinese Journal of Organic Chemistry, 2016 , 36(7) : 1681 -1685 . DOI: 10.6023/cjoc201601034

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