Chinese Journal of Organic Chemistry >
Synthesis and Anti-Hepatitis B Virus Activities of Galactopyranosyl Derivatives of Matijin-Su
Received date: 2015-12-31
Revised date: 2016-03-10
Online published: 2016-03-25
Supported by
Project supported by the National Natural Science Foundation of China (No. 81360472) and the Western Light Talent Culture Project (2014).
To improve the concentration in liver lesion tissue and increase the anti-hepatitis B virus (HBV) activities of Matijin-Su (MTS) derivatives, five hepatic targeting galactopyranosyl derivatives of MTS were synthesized by indirect connecting the liver targeting galactose ligands to MTS using ethanolamin as a linker and their structures were confirmed by 1H NMR, 13CNMR, 1H-1H COSY, HMQC and ESI-MS. The anti-HBV activities of those compounds were evaluated in HepG2 2.2.15 cells. The screening results showed that all target compounds had inhibitory effect on HBV DNA replication in HepG2 2.2.15 cells in a dose-response manner.
Xu Guangcan , Liu Qingchuan , Yuan Jie , Hu Zhanxing , Ma Fangfang , Liang Guangyi , Xu Bixue . Synthesis and Anti-Hepatitis B Virus Activities of Galactopyranosyl Derivatives of Matijin-Su[J]. Chinese Journal of Organic Chemistry, 2016 , 36(7) : 1617 -1625 . DOI: 10.6023/cjoc201512051
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