Chinese Journal of Organic Chemistry >
Recent Advances of Direct Incorporation of Fluorine-Containing Groups and 18F-Labeling Methods
Received date: 2016-01-09
Revised date: 2016-02-16
Online published: 2016-04-15
Fluorine-containing groups have strong electron-withdrawing effect and high lipophilicity, organic molecules incorporated fluorine-containing groups can improve its function. Therefore, the incorporation of fluorine-containing groups into molecules has become the current research hotspot. The method for incorporation of CF3S group becomes one of the hot research field due to its excellent nature. The strategy for incorporation of CF3Se, CF3O and CF3CH2O groups has also been the attention of researchers. 18F has nearly ideal nuclear properties and is the most widely used positron emission tomography (PET) radioisotope for clinical imaging. Therefore, the development of new [18F]radiotracers becomes the research focus of many researchers. The method for 18F-labeling of biomolecules is the key to the development of new [18F]radiotracers. This paper mainly introduce the recently reported methodology of direct incorporating CF3X (X＝S, Se, O, CH2O) groups into molecules and some research results of 18F-labeling methods. Furthermore, some noteworthy research directions in this field are summarized.
Li Gongming , Sun Dequn . Recent Advances of Direct Incorporation of Fluorine-Containing Groups and 18F-Labeling Methods[J]. Chinese Journal of Organic Chemistry, 2016 , 36(8) : 1715 -1740 . DOI: 10.6023/cjoc201601009
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