Chinese Journal of Organic Chemistry >
Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions
Received date: 2016-02-01
Revised date: 2016-03-25
Online published: 2016-04-15
Supported by
Project supported by the Major Natural Science Foundation of Jiangsu Province (No. 14KJA150004), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
In this paper, a series of 13-aryl-6,13-dihydro-3H-quino[4,3-b]pyrrolo[3,2-f]quinolin-12(11H)-one derivatives was synthesized in EtOH under catalyst-free conditions using aromatic aldehydes, 5-aminoindole and 4-hydroxyquinolin-2(1H)- one as reactants. The structure of 4b was confirmed by X-ray diffraction analysis. This procedure has the advantages of simplicity and easy operation. An efficient method for the synthesis of fused pentacyclic heterocycles containing biquinolines moieties is provided.
Key words： quinopyrroloquinoline; 5-aminoindole; catalyst-free; synthesis
Zhao Qun , Yao Changsheng , Wang Xiangshan . Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions[J]. Chinese Journal of Organic Chemistry, 2016 , 36(8) : 1932 -1936 . DOI: 10.6023/cjoc201602001
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