Chinese Journal of Organic Chemistry >
Bromopalladation Triggering the Cascade Oxidative Heterocyclization Reaction of Alkynes with Alkenes in Ionic Liquids
Received date: 2016-03-27
Revised date: 2016-04-14
Online published: 2016-05-17
Supported by
Project supported by the National Natural Science Foundation of China (No.21502055), the Fundamental Research Funds for the Central Universities (No.2015ZM150) and China Postdoctoral Science Foundation (No.2015M572303).
An efficient and practical palladium-catalyzed cascade oxidative heterocyclization has been developed to afford functionalized oxygen-containing five-membered heterocycles in moderate to good yields with high regio- and diastereo-selectivities. Their structures were confirmed by IR, 1H NMR, 13C NMR and HRMS. Furthermore, the current methodology could also be conveniently applied to the synthesis of naturally occurring biologically active functionalized tetrahydrofurans and γ-lactones frameworks.
Key words： palladium-catalyzed; ionic liquids; alkynes; alkenes; heterocycles
An Yanni , Li Jianxiao , Zhang Zhenming , Li Chunsheng , Yang Shaorong . Bromopalladation Triggering the Cascade Oxidative Heterocyclization Reaction of Alkynes with Alkenes in Ionic Liquids[J]. Chinese Journal of Organic Chemistry, 2016 , 36(9) : 2136 -2141 . DOI: 10.6023/cjoc201603043
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