Chinese Journal of Organic Chemistry >
Two New Linear Monoterpenoids from Swertia mussotii
Received date: 2016-03-23
Revised date: 2016-04-29
Online published: 2016-06-01
Supported by
Project supported by the National Science Foundation of China for Distinguished Young Scholar (No.81025023).
Investigation on Swertia mussotii resulted in four compounds by means of various chromatographic techniques (silica gel, Sephadex LH-20, RP-LC and Pre-HPLC). Their structures were determined as (S,2E,6E)-4,8-dihydroxy-2,6-dime-thylocta-2,6-dienoic acid (1), (S,2E,6E)-8-(formyloxy)-4-hydroxy-2,6-dimethylocta-2,6-dienoic acid (2), swerimilegenins B and C (3 and 4) on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D-NMR. Among them, compounds 1 and 2 are two new linear monoterpenoids named as swerimusic acids C (1) and D (2), compounds 3 and 4 are two unusual known secoiridoid aglycones of C9-skeleton obtained for the first time from this plant. Compounds 1~4 were evaluated for their anti-Hepatitis B Virus (HBV) activities on HepG2.2.15 cells line in vitro, but these compounds showed no anti-HBV activity at the maximal tesing concentration. Herin, we only report the isolation and structure elucidation of these compounds.
Cao Tuanwu , He Kang , Geng Chang'an , Zhang Xuemei , Zhou Jun , Chen Jijun . Two New Linear Monoterpenoids from Swertia mussotii[J]. Chinese Journal of Organic Chemistry, 2016 , 36(9) : 2216 -2219 . DOI: 10.6023/cjoc201603038
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