Chinese Journal of Organic Chemistry >
Simple Synthesis of Bicyclic Pyrrole Ketone Compounds
Received date: 2016-04-03
Revised date: 2016-05-13
Online published: 2016-06-02
Supported by
Project supported by the National Natural Science Foundation of China (Nos.U1202221, 21362042, 21662042), the Talent Found in Yunnan Province (No.2012HB001), and the Excellent Young Talents in Yunnan University (No.XT412003).
In this article, a one-pot protocol was established for the synthesis of bicyclic pyrrole ketone compounds. This method based on the building blocks of heterocyclic ketene aminals 1, which reacted with oxalaldehyde 2 in 1,4-dioxane at 50℃ and triethylamine as base. As a result, a series of bicyclic pyrrole ketone compounds 3a~3i have been synthesized. This reaction has some advantages such as simple synthetic route, readily available starting materials, high yields and simple work-up procedures.
Kong Lingbin , Yang Ruixia , Du Xuanxuan , Yan Shengjiao , Lin Jun . Simple Synthesis of Bicyclic Pyrrole Ketone Compounds[J]. Chinese Journal of Organic Chemistry, 2016 , 36(10) : 2437 -2441 . DOI: 10.6023/cjoc201604004
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