Chinese Journal of Organic Chemistry >
Two New Nitrogen Compounds from Gymnotheca involucrata
Received date: 2016-04-06
Revised date: 2016-05-08
Online published: 2016-06-02
Supported by
Project supported by the National Natural Sciences Foundation of China (No.31560102).
By silica gel, MCI column chromatographic and preparative HPLC (high performance liquid chromatography) technologies, six nitrogen compounds were isolated from the whole parts of Gymnotheca involucrata. By using spectroscopic techniques including NMR and MS, these compounds were identified as 2-(1-hydroxy-6-methoxy-4-oxocyclohexa-2-ene- 1-yl)acetonitrile (1), 10-methoxy-1-oxa-3-azaspiro[4.5]dec-2,6-diene-8-one (2), 2-(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)- acetonitrile (3), 1-oxa-3-azaspiro[4.5]dec-2-ene-8-one (4), 1-oxa-3-azaspiro[4.5]dec-2,6-diene-8-one (5) and 4-hydroxybenzyl acetonitrile (6). Compounds 1 and 2 are new compounds, compound 3 is a new natural product, and compounds 4~6 were isolated from this plant for the first time.
Xiao Shiji , Xu Delin , Fu Shaobin , Zhang Maosheng , Ding Lisheng , Zhou Yan . Two New Nitrogen Compounds from Gymnotheca involucrata[J]. Chinese Journal of Organic Chemistry, 2016 , 36(10) : 2496 -2498 . DOI: 10.6023/cjoc201604012
[1] Chen, Y. Q. Flora of China, Vol. 20(1), Science Press, Beijing, 1982(in Chinese). (程用谦, 中国植物志, 第20(1)卷, 科学出版社, 北京, 1982.)
[2] Zhang, H. Y.; Zhang, Z. Y. The Chinese Traditional Medicine Resource Records, Science Press, Beijing, 1994(in Chinese). (张惠源, 张志英, 中国中药资源志要, 科学出版社, 北京, 1994.)
[3] Yang, W. L.; Tian, J.; Ding, L. S. Chin. J. Chin. Mater. Med. 2001, 26, 43(in Chinese). (杨维力, 田军, 丁立生, 中国中药杂志, 2001, 26, 43.)
[4] Xiao, S. J.; Lei, X. X.; Xia, B.; Xu, D. Q.; Xiao, H. P.; Xu, H. X.; Chen, F.; Ding, L. S.; Zhou, Y. Tetrahedron. Lett. 2014, 55, 5949.
[5] Chen, B. Q.; Yang, Z. B.; Cao, N. F.; Zhao, L.; Kan, W. Y. Chin. Tradit. Pat. Med. 2011, 33, 677(in Chinese). (陈百泉, 杨再波, 曹乃锋, 赵琳, 康文艺, 中成药, 2011, 33, 677.)
[6] Yang, Z. B.; Long, C. M.; Mao, H. L.; Sun, C. B. Food Ind. 2011, 4, 79(in Chinese). (杨再波, 龙成梅, 毛海立, 孙成斌, 食品工业, 2011, 4, 79.)
[7] Fischer, A.; Henderson, G. N. Tetrahedron Lett. 1983, 24, 131.
[8] Xiao, S. J.; Guo, D. L; Chen, F.; Ding, L. S.; Zhou, Y. J. Asian Nat. Prod. Res. 2016, 18, 719.
[9] Yao, S. Y.; Ma, Y. B.; Tang, Y.; Chen, J. J.; Zhang, X. M. Chin. J. Chin. Mater. Med. 2008, 33, 1418(in Chinese). (姚淑英, 马云保, 唐亚, 陈纪军, 张雪梅, 中国中药杂志, 2008, 33, 1418.)
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