Chinese Journal of Organic Chemistry >
Synthesis and Biological Activities of Novel Cyanoacrylates Containing 1,3,4-Oxadiazole Moiety
Received date: 2016-05-17
Revised date: 2016-06-06
Online published: 2016-06-20
Supported by
Project supported by the National Natural Science Foundation of China (No.21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No.2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (Nos.AS2014011, CP12013002, MS22015020).
In order to find new cyanoacrylate lead compounds, a series of novel cyanoacrylates carrying 1,3,4-oxadiazole moiety were prepared by the method of active substructure combination. The structures of the title compounds were characterized by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data displayed that in postemergence treatment compound 8b had 80% herbicidal activity against Stellaria media at 1500 g/ha and compound 8j showed 70% herbicidal activity against Chenopodium serotinum L. at 1500 g/ha. Additionally, compounds 8e, 8k, 8m and 8n exhibited good anti-tumor activity against HepG2 cells with the IC50values of 8.2, 5.9, 8.0 and 12.6 μmol/L, respectively.
Key words： 1,3,4-oxadiazole; 2-cyanoacrylates; synthesis; biological activity
Shi Yujn , Li Yang , Fang Yuan , Chen Jia , Ye Linyu , Ge Shushan , Dai Hong . Synthesis and Biological Activities of Novel Cyanoacrylates Containing 1,3,4-Oxadiazole Moiety[J]. Chinese Journal of Organic Chemistry, 2016 , 36(10) : 2472 -2478 . DOI: 10.6023/cjoc201605029
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