Chinese Journal of Organic Chemistry >
Synthesis of Quinoline Derivatives Catalyzed by α-Chymotrypsin
Received date: 2016-04-24
Revised date: 2016-06-02
Online published: 2016-07-07
Supported by
Project supported by the National Natural Science Foundation of China (Nos.21262002,21462001,21465002),the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT13054),the Natural Science Foundation of Jiangxi Province (No.20142BAB203008).
The α-chymotrypsin-catalyzed Friedländer condensation reaction between 2-aminoaryl ketone and α-methylene ketone was firstly reported, and a series of quinoline derivatives were obtained in moderate to excellent yields. This method is easy to operate and the reaction condition is mild, which not only expands the application of the promiscuity of protease, but also has positive significance for promoting the development of the green chemistry.
Key words： α-chymotrypsin; Friedlä; nder condensation; quinoline derivatives; biocatalysis
Liang Meng , Xie Zongbo , Ai Feng , Le Zhanggao . Synthesis of Quinoline Derivatives Catalyzed by α-Chymotrypsin[J]. Chinese Journal of Organic Chemistry, 2016 , 36(11) : 2704 -2708 . DOI: 10.6023/cjoc201604051
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