Chinese Journal of Organic Chemistry >
Synthesis and Antitumor Activities of Cholestane Derivatives with a Structure of 3-Hydroxy-6-hydrazone or 6-Carbonyl-3-hydrazone
Received date: 2016-04-04
Revised date: 2016-06-17
Online published: 2016-08-12
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21562007, 21462009), the Science Research Project of Guangxi Teachers University (No. KY2015D077) and the Organic Chemistry in Guangxi University Key Disciplines.
Some cholestane hydrazone derivatives with a structure of 3-or 6-hydrazone group were synthesized by different chemical methods using cholesterol as a starting material, and their structures were characterized by IR, NMR and HRMS. The antiproliferative activity of the compounds in vitro was evaluated against human Bel-7404 and SGC-7901 cancer cells. The results showed that the cholestane derivatives with the structure of 3-hydroxy-6-hydrazone exhibited distinct cytotoxicity. The information obtained from the studies is valuable for the design of novel steroidal chemotherapeutic drugs.
Cui Jianguo , Liu Chang , Liu Liang , Gan Chunfang , Lu Yan , Chen Shuang , Dong Xin , Huang Yanmin . Synthesis and Antitumor Activities of Cholestane Derivatives with a Structure of 3-Hydroxy-6-hydrazone or 6-Carbonyl-3-hydrazone[J]. Chinese Journal of Organic Chemistry, 2016 , 36(12) : 2933 -2940 . DOI: 10.6023/cjoc201604007
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