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Chinese Journal of Organic Chemistry >

2016 , Vol. 36 >Issue 12: 2981 - 2985

DOI: https://doi.org/10.6023/cjoc201604037

NOTE

Synthesis and Antitumor Activities of Alkyl 4-(Bis(4-fluorophenyl)-methyl)piperazine-1-carbodithioate Derivatives

  • Deng Jie ,
  • Li Ainuan ,
  • Li Qinghan ,
  • Ding Yong ,
  • Yang XueJun ,
  • Chen Feng
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  • College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041

Received date: 2016-04-18

  Revised date: 2016-07-19

  Online published: 2016-08-22

Supported by

Project supported by the Sichuan Provincial Department of Science and Technology (No. 2015NZ0033) and the Southwest University for Nationalities Students Innovation and Entrepreneurship Training (No. S201510656121).

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Abstract

Thirteen new alkyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioatee derivatives were synthesized with 1-(bis(4-fluorophenyl)methyl)piperazine, substituted benzyl or alkyl bromide and methane-dithione as starting material in the presence of K3PO4. Their structures were determined by IR, MS and 1H NMR. Preliminary bioassay indicated that twelve compounds exhibited good activities against CDC25B (the inhibition rates up to 99% at the concentration of 20 μg/mL), three compounds exhibited a certain degree against Leukemia HL-60 cell (the inhibition rates up to 54.59% at the concentration of 40 μmol/L).

Key words： 1-(bis(4-fluorophenyl)methyl)piperazine; carbodithioate; organic synthesis; antitumor activity

Cite this article

Deng Jie , Li Ainuan , Li Qinghan , Ding Yong , Yang XueJun , Chen Feng . Synthesis and Antitumor Activities of Alkyl 4-(Bis(4-fluorophenyl)-methyl)piperazine-1-carbodithioate Derivatives[J]. Chinese Journal of Organic Chemistry, 2016 , 36(12) : 2981 -2985 . DOI: 10.6023/cjoc201604037

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