Chinese Journal of Organic Chemistry >
Synthesis and Fungicidal Activity of Diamide Compounds Based on the Metabolite of Benalaxyl
Received date: 2016-08-10
Revised date: 2016-08-31
Online published: 2016-09-08
Supported by
Project supported by National Science Foundation for Fostering Talents in Basic Research of China(No. J1210064) and the National Natural Science Fondation of China(No. 21337005).
Based on benalaxyl pesticide metabolite structure framework,fourteen novel diamide derivatives were synthesized by the reaction of amine and N2-carboxyacetyl-N1-(2,6-dimethylphenyl) alanine methyl ester.Their structures were identified by 1H NMR,13C NMR spectra and HRMS.The results of bioassay indicated that some compounds possess potential fungicidal activities against 8 kinds of bacteria,and the antibacterial activity of some compounds was better than that of benalaxyl.At a dosage of 5.0×10-5 g/mL,compound 7d displayed 94.2% antifungal activities against Rhizoctonia solani.Compound 8f displayed 87.1% and 88.9% antifungal activities against Phytophthora capsici and Rhizoctonia solani.
Key words： benalaxyl; metabolite; diamide; synthesis; antifungal activity
Sun Guoshao , Wang Lingna , Jin Shuhui , Dong Yanhong , Lu Huizhe , Zhang Jianjun . Synthesis and Fungicidal Activity of Diamide Compounds Based on the Metabolite of Benalaxyl[J]. Chinese Journal of Organic Chemistry, 2017 , 37(1) : 157 -165 . DOI: 10.6023/cjoc201608006
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