Chinese Journal of Organic Chemistry >
Efficient Synthesis of Epilactose
Received date: 2016-08-17
Revised date: 2016-10-08
Online published: 2016-11-03
Supported by
Project supported by the National Science & Technology Pillar Program of China (No. 2015BAK45B01).
Epilactose (4-O-β-D-galactopyranosyl-D-mannose) is a reducing disaccharide with satisfactory prebiotic properties. A superior synthetic methods were confirmed by screening different coupled donors and acceptors which were synthesized from D-mannose and D-galactose, respectively. This route gets 50% overall yields and all the intermediates are easily to be purified, making the route suitable for large scale preparation of the target compound. All the compounds were characterized by NMR and HRMS spectra.
Key words： epilactose; D-mannose; D-galactose; synthesis
Wang Jiayao , Jiang Rui , Liang Xiaomei , Jin Shuhui , Wang Daoquan , Zhang Jianjun . Efficient Synthesis of Epilactose[J]. Chinese Journal of Organic Chemistry, 2017 , 37(2) : 375 -384 . DOI: 10.6023/cjoc201608010
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