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Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives
Received date: 2016-08-22
Revised date: 2016-11-02
Online published: 2016-11-17
Supported by
Project supported by the National Natural Science Foundation of China (No. 21502074) and the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006).
A rapid and efficient ultrasound-assisted method for the synthesis of 2-thioxo-2H-thiopyran and 2-amino-6-thioxodihydropyridine derivatives by the reaction of 2-(1-phenylethylidene)malononitrile and carbon disulfide or isothiocy-anatobenzene catalyzed by NaOH has been developed. This protocol has the advantages of simple operation, short reaction times, high yields, and environmental friendliness. The structures of all the products were characterized by 1H NMR, 13C NMR, IR and MS techniques. The reported method is the efficient approach for the synthesis of 2-thioxo-2H-thiopyran and 2-amino-6-thi-oxodihydropyridine derivatives.
Lin Wei , Zheng Yongxiang , Huang Zhibin , Shi Daqing . Rapid and Efficient Ultrasound-Assisted Method for the Synthesis of 2-Thioxo-2H-thiopyran and 2-Amino-6-thioxodihydropyridine Derivatives[J]. Chinese Journal of Organic Chemistry, 2017 , 37(2) : 508 -513 . DOI: 10.6023/cjoc201608017
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