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An Efficient Synthesis of Benzothieno-[3',2': 2,3]pyrido[4,5-d]thiazolo[3,2-a]pyrimidin-5-ones
Received date: 2016-09-29
Revised date: 2016-11-07
Online published: 2016-11-22
Supported by
Project supported by the Innovation Team Project of Liaoning Province Education Department (No. 2015001).
A series of novel benzothieno[3',2':2,3]pyrido[4,5-d]thiazolo[3,2-a]pyrimidinone derivatives are prepared via sulfamic acid-catalyzed Pictet-Spengler cyclization of 7-(3-amino-5-phenylaminothiazolo-2-yl) thiazolo[3,2-a]pyrimidin-5-one, which in turn were obtained from the Thorpe-Ziegler isomerization of 7-(chloromethyl)thiazolo[3,2-a]pyrimidin-5-one with 2-mercaptobenzonitrile. The method was characterized with raw material easy to get, mild reaction conditions, good yields and a facile and efficient synthetic method of novel fused pyrimidines.
Wang Dong , Wang Daolin , Qian Jianhua . An Efficient Synthesis of Benzothieno-[3',2': 2,3]pyrido[4,5-d]thiazolo[3,2-a]pyrimidin-5-ones[J]. Chinese Journal of Organic Chemistry, 2017 , 37(3) : 698 -703 . DOI: 10.6023/cjoc201609031
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