Chinese Journal of Organic Chemistry >
Synthesis and Herbicidal Activities of Novel Cyanoacrylate Derivatives Containing Substituted Pyrimidine Moiety
Received date: 2016-08-24
Revised date: 2016-09-21
Online published: 2016-12-21
Supported by
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (Nos. AS2014011, CP12013002, MS22015020).
In search of novel cyanoacrylate compounds with potent bioactivity, a series of new cyanoacrylates bearing substituted pyrimidine moiety were obtained by the method of active substructure combination. The title compounds were structurally confirmed by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data indicated that some target compounds showed good herbicidal activities. In postemergence treatment, compounds 9a and 9b had 90% and 100% herbicidal activity against Brassica juncea at 1500 g/ha, compounds 9a and 9b showed 90% and 100% herbicidal activity against Stellaria media at 1500 g/ha, and compounds 9a and 9b displayed 95% and 100% inhibitory rates against Chenopodium serotinum L. at 1500 g/ha. When the dosage was reduced to 750 g/ha, compound 9b exhibited all 100% herbicidal effect against Brassica juncea, Stellaria media, and Chenopodium serotinum L. in postemergence treatment. Even at 375 g/ha, compound 9b was still active against Brassica juncea, Stellaria media, and Chenopodium serotinum L. in postemergence treatment with the inhibition rates of 90%, 80% and 90%, respectively.
Key words： substituted pyrimidine; cyanoacrylates; synthesis; herbicidal activities
Dai Hong , Fang Yuan , Li Yang , Wang Xianglong , Xiang Xingbang , Ge Shushan , Shi Yujun . Synthesis and Herbicidal Activities of Novel Cyanoacrylate Derivatives Containing Substituted Pyrimidine Moiety[J]. Chinese Journal of Organic Chemistry, 2016 , 36(12) : 2973 -2980 . DOI: 10.6023/cjoc201608022
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