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Chinese Journal of Organic Chemistry >

2017 , Vol. 37 >Issue 4: 1033 - 1039

DOI: https://doi.org/10.6023/cjoc201612039

NOTE

Chemical Constituents from the Cultures of Fungus Xylaria polymorpha

  • Yang Ningning ,
  • Kong Fandong ,
  • Ma Qingyun ,
  • Huang Shengzhuo ,
  • Luo Duqiang ,
  • Zhou Liman ,
  • Dai Haofu ,
  • Yu Zhifang ,
  • Zhao Youxing
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  • a. College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095;
    b. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101;
    c. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, College of Life Science, Baoding 071002

Received date: 2016-12-12

  Revised date: 2016-12-22

  Online published: 2017-01-04

Supported by

Project supported by the Special Fund for Agro-Scientific Research in the Public Interest (No. 201303117), the Fundamental Scientific Research Funds for Chinese Academy of Tropical Agricultural Sciences (No. 1630052016008) and the Natural Science Foundation of Hainan Province (No. 20153143).

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Abstract

Totally 21 compounds were isolated from the EtOAc extract of fermentation broth of fungus Xylaria polymorpha (Pers.: Fr.) Grer, including two new drimane-type sesquiterpenoids named polymorphines A and B (1~2) and one new phenyloxolane compound named 2-methyl-2-(4-hydroxymethylphenyl) oxolane (3), together with 18 known compounds 4~21. The structures of these compounds were elucidated by NMR and single-crystal X-ray diffraction analysis. Compound 2 exhibited anti-acetylcholinesterase and α-glucosidase inhibitory activities. Moreover, compound 3 showed moderate inhibitory activitiy against the nematode Panagrellus redivivus with mortality ratio of 59.6% at 2.5 mg/mL.

Key words： Xylaria polymorpha; sesquiterpene; AChE inhibitory activity; α-glucosidase inhibitory activity; anti-nematode activity

Cite this article

Yang Ningning , Kong Fandong , Ma Qingyun , Huang Shengzhuo , Luo Duqiang , Zhou Liman , Dai Haofu , Yu Zhifang , Zhao Youxing . Chemical Constituents from the Cultures of Fungus Xylaria polymorpha[J]. Chinese Journal of Organic Chemistry, 2017 , 37(4) : 1033 -1039 . DOI: 10.6023/cjoc201612039

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