Chinese Journal of Organic Chemistry >
Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives
Received date: 2016-10-17
Revised date: 2016-12-11
Online published: 2017-01-10
Supported by
Project Supported by the National Natural Science Foundation of China (No. 21602118), and the Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).
In order to find efficient, low toxicity, eco-friendly insecticides, novel chiral carbon and sulfur phthalic acid diamide derivatives containing pyridine substitute were designed and synthesized for further studying the structure-activity relationship of dual-chiral sulfilimines and sulfoximines. Their structures were confirmed by NMR and HRMS. The preliminary results of biological evaluation showed that the most compounds exhibited moderate larvicidal activity. These results provide a theoretical basis for the study of the dicarboxamide structures containing sulfiliminyl and sulfoximinyl moieties.
Key words： pyridine; phthalic acid diamides; synthesis; insecticidal activity; dual-chiral
Meng Xiangde , Zhou Sha , Xie Yongtao , Zhao Yu , Xiong Lixia , Zhou Sha , Li Zhengming . Design, Synthesis and Biological Activities of Novel Dual-Chiral Carbon and Sulfur Pyridine Phthalic Acid Diamide Derivatives[J]. Chinese Journal of Organic Chemistry, 2017 , 37(4) : 908 -913 . DOI: 10.6023/cjoc201610027
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