Chinese Journal of Organic Chemistry >
One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder
Received date: 2016-11-04
Revised date: 2016-12-26
Online published: 2017-01-10
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21262031, 21462037).
An one-pot reaction of trifluoroacetaldehyde methyl hemiacetal or trifluoroketones, acylhydrazines and allyl bromide promoted by indium powder is reported, and a series of trifluoromethylated homoallylic N-acylhydrazines were obtained with good to excellent yields. The features of this process include readily available starting materials as trifluoromethyl building blocks, mild conditions and easy operation.
Li Jun , Yang Tianyu , Zhang Huaiyuan , Huang Danfeng , Wang Kehu , Su Yingpeng , Hu Yulai . One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder[J]. Chinese Journal of Organic Chemistry, 2017 , 37(4) : 925 -935 . DOI: 10.6023/cjoc201611009
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