Chinese Journal of Organic Chemistry >
A Concisely Convergent Synthesis of Berberine Chloride
Received date: 2016-12-02
Revised date: 2017-01-01
Online published: 2017-01-17
Supported by
Project supported by the Graduate Innovative Research Projects of Central Universities, Southwest University for Nationalities (No. CX2015SZ045) and the Research Projects Sichuan Provincial Department of Education (No. 15ZB0487).
The berberine chloride was synthesized starting from benzo[d][1,3]dioxole with the mild condition and the simple operation in overall 33% yield. The route includes the five steps of nucleophilic ring opening, deprotection and cyclization and so on. All intermediates were determined by 1H NMR, 13C NMR and MS techniques.
Chen Cheng , Xu Mengmeng , Zhao Qing , Liu Chengxiu , Yang Hongjun , Feng Yuchuan . A Concisely Convergent Synthesis of Berberine Chloride[J]. Chinese Journal of Organic Chemistry, 2017 , 37(2) : 503 -507 . DOI: 10.6023/cjoc201612005
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