Chinese Journal of Organic Chemistry >
An Efficient Synthesis of 2-Vinyl Furans/Thiophenes: Oxidative Heck Coupling under High-Speed Ball-Milling Conditions
Received date: 2016-12-18
Revised date: 2017-02-08
Online published: 2017-02-15
Supported by
Project supported by the Special Program for Key Basic Research of the Ministry of Science and Technology of China (No. 2014CB460608) and the National Natural Science Foundation of China (Nos. 21406201, 21276237).
An efficient synthesis of 2-vinyl furans and thiophenes through oxidative Heck reaction has been explored under solvent-less high-speed ball-milling conditions. This Pd-catalyzed oxidative Heck reaction proceeded well with both acrylates and styrenes, which afford desired product in 45 min, with moderate to high yields.
Key words： high-speed ball-milling; oxidative Heck coupling; furan; thiophene
Jia Kanyan , Jiang Zhijiang , Yu Jingbo , Hong Zikun , Su Weike . An Efficient Synthesis of 2-Vinyl Furans/Thiophenes: Oxidative Heck Coupling under High-Speed Ball-Milling Conditions[J]. Chinese Journal of Organic Chemistry, 2017 , 37(6) : 1473 -1478 . DOI: 10.6023/cjoc201612047
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