Chinese Journal of Organic Chemistry >
One-Pot Synthesis of Multisubstituted Chromone-Fused Bicyclic Pyridine Compounds
Received date: 2016-12-12
Revised date: 2017-01-21
Online published: 2017-02-20
Supported by
Project supported by the National Natural Science Foundation of China (Nos. U1202221, 21362042, 21262042, 21662042), the Talent Found in Yunnan Province (No. 2012HB001), and the Excellent Young Talents of Yunnan University (No. XT412003).
A concise and environment friendly route for the synthesis of multisubstituted chromone-fused bicyclic pyridine compounds via one-step reaction of chromone-3-carboxaldehyde 1 and N-benzyl nitro ketene aminals (NBNKAs, 2) in ethanol media has been developed. The targeted compounds 3 can efficiently obtain by filter without extra post-treatment. The reaction is particularly attractive due to following features: low-cost and biocompatibility solvent, mild temperature, atom economy, high yields, and potential biological activity.
Key words： environment friendly; atom economy; catalyst-free; bicyclic pyridine; neonicotinoids
Chen Liang , Wang Baoqu , Zhao Yucheng , Yan Shengjiao , Lin Jun . One-Pot Synthesis of Multisubstituted Chromone-Fused Bicyclic Pyridine Compounds[J]. Chinese Journal of Organic Chemistry, 2017 , 37(6) : 1433 -1442 . DOI: 10.6023/cjoc201612038
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