Chinese Journal of Organic Chemistry >
Synthesis and Biological Activity of Novel 3-Phenylpropan-1-one Oxime Ethers Containing Pyridine Moiety
Received date: 2017-01-04
Revised date: 2017-02-12
Online published: 2017-02-27
Supported by
Project supported by the Natural Science Foundation of Shandong Province (No. ZR2014BM030).
To search for the pyridine pesticide lead compound with high antigungal activity, a series of novel 3-phenyl propan-1-one oxime ethers bearing pyridine moiety were synthesized using 3-acetypyridine, benzaldehyde, substituted anilines and alkoxyamine hydrochlorides as starting materials. The structures of target compounds were determined by IR, 1H NMR, 13C NMR and elemental analysis. Meanwhile, the target compounds were evaluated for their antifungal activities against S. sclerotiorum and B. cinerea by the mycelium growth rate method. The results indicated that some compounds displayed high antifungal activity to the two kinds of pathogenic fungi, and their activities were even higher than that of the positive control, chlorothalonil.
Key words： heterocycles; pyridine; ketones; oxime ethers; biological activitity
Zan Ningning , Wan Fuxian , Wang Shichun , Zhang Junhui , Jiang Lin . Synthesis and Biological Activity of Novel 3-Phenylpropan-1-one Oxime Ethers Containing Pyridine Moiety[J]. Chinese Journal of Organic Chemistry, 2017 , 37(6) : 1537 -1541 . DOI: 10.6023/cjoc201701009
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