Chinese Journal of Organic Chemistry >
Diterpenoids from the Needles of the Endangered Plant Pinus dabeshanensis and Their Protein Tyrosine Phosphatase 1B Inhibitory Effects
Received date: 2017-01-04
Revised date: 2017-02-19
Online published: 2017-03-08
Supported by
Project supported by the National Natural Science Foundation of China (Nos.21472021,81273401,81202420),the Ph.D.Programs Foundation of Ministry of Education of China (Nos.20120071110049,20120071120049),and the National Basic Research Program of China (973 Program,No.2013CB530700).
One new, dabeshanensin L (1), and nine known diterpenoids with diverse structures were isolated from the 90% MeOH extract of the needles (30 g dried mass-limited samples) of Pinus dabeshanensis, an endangered conifer listed in the China Plant Red Data Book (CPRDB). The new structure was established by detailed analysis of its spectroscopic data (IR, 1D/2D NMR, HRMS). Among the isolates, isopimara-7-en-18-oic acid (4), trans-abienol (6), and lambertianic acid (8) showed significant inhibitory activities against the human protein tyrosine phosphatase 1B (PTP1B) enzyme, a key target for the treatment of type-Ⅱ diabetes and obesity, with IC50 values ranging from 14.6 to 37.7 μmol/L.
Li Ming , Hu Changlin , Han Han , Xiong Juan , Hu Jinfeng . Diterpenoids from the Needles of the Endangered Plant Pinus dabeshanensis and Their Protein Tyrosine Phosphatase 1B Inhibitory Effects[J]. Chinese Journal of Organic Chemistry, 2017 , 37(7) : 1860 -1863 . DOI: 10.6023/cjoc201701002
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