Chinese Journal of Organic Chemistry >
Research Progress in Structural Modification of Antimycin A
Received date: 2017-02-09
Revised date: 2017-03-03
Online published: 2017-03-08
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21472063, 21502062), the Hubei Provincial Department of Education (No. Q20102606), the Xiangyang Science and Technology Bureau (No. 2010GG1B33), and the Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices (No. HLOM151005).
Antimycin A is a class of natural products bearing a dilactone-ring moiety as the core skeleton. These compounds have been identified as specific inhibitors of the mitochondrial respiratory chain and bind to the Qi site of the cytochrome bc1 complex. Due to its unique structure and extremly high activity, it has aroused great interest of researchers. The development and biological activities of antimycin A are mainly described, and the recent results of its structural modifications are summarized.
Key words： antimycin A; inhibitor; biological activity; structural modification
Cheng Hua , Nie Ren , Wang Wanqiang , Huang Lin , Liu Ke , Chen Cheng , Wu Qiongyou . Research Progress in Structural Modification of Antimycin A[J]. Chinese Journal of Organic Chemistry, 2017 , 37(6) : 1368 -1381 . DOI: 10.6023/cjoc201702010
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