Chinese Journal of Organic Chemistry >
Total Synthesis of Marine Furanosesterterpene Natural Product, (18S)-Variabilin
Received date: 2017-02-08
Revised date: 2017-03-13
Online published: 2017-04-01
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21472129, 21272163).
(18S)-Variabilin is the representative furanosesterterpenes, which exhibits varieties of bioactivities. Starting from geraniol and the key chiral segment prepared via Evans' asymmetric alkylation protocol, (18S)-variabilin has been totally synthesized in the longest linear 13 steps involving Julia-Lythgoe coupling reaction and aldol-type condensation.
Key words： variabilin; furanosesterterpenes; asymmetric total synthesis
Xiong Weiyan , Zhao Yingchun , Xu Liang , Ji Hong . Total Synthesis of Marine Furanosesterterpene Natural Product, (18S)-Variabilin[J]. Chinese Journal of Organic Chemistry, 2017 , 37(8) : 2101 -2108 . DOI: 10.6023/cjoc201702007
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