Chinese Journal of Organic Chemistry >
Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity
Received date: 2017-02-16
Revised date: 2017-03-09
Online published: 2017-04-01
Supported by
Project supported by the National Natural Science Foundation of China (No.81402803),the Small Molecule Natural Medicine Innovation Team (No.15TD0048),the Research Foundation for Educational Commission of Sichuan Province (No.15ZB0140) and the Fundamental Research Funds for Central Universities (No.2682017QY04).
A new C18 diterpenoid alkaloid,leucostonine(1),was isolated from the whole plant of Aconitum leucostomum Vorosch.,together with twelve known diterpenoid alkaloids.Their structures were elucidated on the basis of extensive spectroscopic analysis,including HR-ESI-MS,1D NMR and 2D NMR spectra.12 compounds were tested for their antifeedant activity against larvae of Spodoptera exigua Hiibner.Anthranoyllycoctonine and avadharidine showed considerable potent antifeedant activity(EC50<1 mg/cm2),followed by N-acetylsepaconitine,finaconitine and N-deacetylappaconitine(EC50<2 mg/cm2).
Chen Lin , Wang Qian , Huang Shuai , Shan Lianhai , Gao Feng , Zhou Xianli . Diterpenoid Alkaloids from Aconitum leucostomum and Their Antifeedant Activity[J]. Chinese Journal of Organic Chemistry, 2017 , 37(7) : 1839 -1843 . DOI: 10.6023/cjoc201702021
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