Chinese Journal of Organic Chemistry >
Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster
Received date: 2017-02-27
Revised date: 2017-04-01
Online published: 2017-04-13
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21173176, 21673190) and the Fundamental Research Funds for the Central Universities (No. 20720150040).
As one of the most abundant metals on earth, iron is cheap and low toxicity. Herein we reported the asymmetric transfer hydrogenation of (ATH) ketones catalyzed by the system generated in situ from chiral multidentate aminophosphine ligand (R,R,R,R)-PN4H6 and Fe3(CO)12. The effects of temperature and additive on the ATH of propiophenone were examined. After optimizing the reaction conditions, we applied the catalytic system to the ATH of various aromatic ketones, obtaining the corresponding optical active alcohols with high enantioselectivities (up to 96% ee).
Wu Fang , Zhang Wenjing , An Dongli , Li Yanyun , Gao Jingxing . Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster[J]. Chinese Journal of Organic Chemistry, 2017 , 37(5) : 1295 -1299 . DOI: 10.6023/cjoc201702043
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