Chinese Journal of Organic Chemistry >
Reaction of 2-Methylquinoline and 2-Methylpyridine with Aromatic Aldehydes in High Temperature Water
Received date: 2016-12-25
Revised date: 2017-03-29
Online published: 2017-04-18
Alkyl aza-arene derivatives were synthesized in high-temperature water without catalyst. The effects of temperature, reaction time, molar ratio of reactants and amount of water on the reaction were investigated. The results indicate that it is an efficient way to synthesize 2-methylquinoline derivatives and 2-methylpyridine derivatives from 2-methylquinoline and 2-methylpyridine with various aromatic aldehydes by C－H bond activation. This process is clean and easy to operate.
Xiao Shangyou , Bi Jingfu , Mu Xiaojing , Zhou Zhao , Xu Guang . Reaction of 2-Methylquinoline and 2-Methylpyridine with Aromatic Aldehydes in High Temperature Water[J]. Chinese Journal of Organic Chemistry, 2017 , 37(8) : 2159 -2164 . DOI: 10.6023/cjoc201612058
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