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Chinese Journal of Organic Chemistry >

2017 , Vol. 37 >Issue 10: 2705 - 2710

DOI: https://doi.org/10.6023/cjoc201704032

ARTICLE

Design,Synthesis,Fungicidal Activity and Docking Study of Acyl Thiourea Derivatives Containing Pyrazole Moiety

  • Sun Nabo ,
  • Shen Zhonghua ,
  • Zhai Zhiwen ,
  • Han Liang ,
  • Weng Jianquan ,
  • Tan Chengxia ,
  • Liu Xinghai
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  • a College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015;
    b College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Received date: 2017-04-18

  Revised date: 2017-06-02

  Online published: 2017-06-16

Supported by

Project supported by the Natural Science Foundation of Zhejiang Province (No.LY16C14007) and the National Natural Science Foundation of China (No.31401691).

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Abstract

A series of novel acyl thiourea derivatives containing pyrazole moiety were designed and synthesized from ethyl acetoacetate, triethyl orthoformate, methylhydrazine by multi-step reactions. Their structures were characterized by 1H NMR, 13C NMR and HRMS. The target compounds were evaluated for their fungicidal activity. The results indicated that some of the title compounds displayed certain fungicidal activities against Botryospuaeria berengeriana. The docking results indicated that the hydrogen bond and π(σ)-π interaction formed between N-((2,6-diethylphenyl)carbamothioyl)-1,3-dimethyl-1H-pyrazole-4-carboxamide (6k) and succinodehydrogenase.

Key words： pyrazole; acyl thiourea; synthesis; fungicidal activity; docking

Cite this article

Sun Nabo , Shen Zhonghua , Zhai Zhiwen , Han Liang , Weng Jianquan , Tan Chengxia , Liu Xinghai . Design,Synthesis,Fungicidal Activity and Docking Study of Acyl Thiourea Derivatives Containing Pyrazole Moiety[J]. Chinese Journal of Organic Chemistry, 2017 , 37(10) : 2705 -2710 . DOI: 10.6023/cjoc201704032

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