Chinese Journal of Organic Chemistry >
One-Step Synthesis of Isoquinolinone Compounds
Received date: 2017-05-27
Revised date: 2017-07-06
Online published: 2017-07-18
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21362042, 21662042, U1202221, 21262042), the Natural Science Foundation of Yunnan Province (No. 2017FA003), the Talent Found in Yunnan Province (No. 2012HB001), the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University (No. XT412003).
A concise and efficiently route for the synthesis of isoquinolinones via one-step reaction of nitro substituted methyl 2-fluorobenzoate 1 and heterocyclic ketone aminals (HKAs, 2) in 1,4-dioxane catalyzed by Cs2CO3 under reflux conditions has been developed. Isoquinolinones 3 were obtained by one-step strategy. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.
Wang Baoqu , Kong Lingbin , Luo Qin , Lin Jun , Yan Shengjiao . One-Step Synthesis of Isoquinolinone Compounds[J]. Chinese Journal of Organic Chemistry, 2017 , 37(11) : 2972 -2977 . DOI: 10.6023/cjoc201705038
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