Chinese Journal of Organic Chemistry >
Direct 3-Arylsulfenylation of Indoles with Thiols in Basic Ionic Liquid
Received date: 2017-07-05
Revised date: 2017-08-16
Online published: 2017-08-18
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21502055, 21642005), the Fundamental Research Funds for the Central Universities (No. 2015ZM150) and the China Postdoctoral Science Foundation (No. 2016T90779).
An efficient and convenient transition metal-free procedure for the synthesis of 3-sulfenylindoles derivatives in moderate to good yields from readily available indoles and thiols in basic ionic liquid has been developed. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. This sulfenylation process provides a novel route for directly accessing 3-sulfenylindoles in good to excellent yields and good functional group tolerance with high atom efficiency. Notably, the current methodology could also be conveniently applied to the synthesis of thioarylated naturally occurring biologically active frameworks.
Key words： ionic liquids; indoles; thiols; 3-arylsulfenylation reaction
Cen Jinghe , Yang Kai , Li Jianxiao , Li Can , Yang Shaorong . Direct 3-Arylsulfenylation of Indoles with Thiols in Basic Ionic Liquid[J]. Chinese Journal of Organic Chemistry, 2017 , 37(12) : 3213 -3219 . DOI: 10.6023/cjoc201707005
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