Chinese Journal of Organic Chemistry >
Synthesis and Biological Activities of Novel Pyrazole Oxime Esters Containing Substituted Pyrazolyl Group
Received date: 2017-07-21
Revised date: 2017-08-21
Online published: 2017-09-08
Supported by
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (No. MS22015020).
In order to explore novel pyrazole derivatives with good biological activities, a series of pyrazole-containing pyrazole oxime esters were designed and synthesized according to the method of active substructure combination. Their structures were determined by 1H NMR, 13C NMR spectra and elemental analysis. The preliminary bioactivity test showed that some of the target compounds had good insecticidal activity against Aphis medicaginis at a concentration of 500 μg/mL, some title compounds displayed good insecticidal activity against Nilaparvata lugens at 500 μg/mL. In addition, some of the designed compounds exhibited certain anti-tumor activity against HepG2 cells.
Key words： pyrazol; pyrazole oxime; synthesis; bioactivity
Dai Hong , Huang Meiling , Ge Shushan , Sun Siyu , Shen Aibao , Cheng Xiaoyan , Li Chunjian , Shi Jian . Synthesis and Biological Activities of Novel Pyrazole Oxime Esters Containing Substituted Pyrazolyl Group[J]. Chinese Journal of Organic Chemistry, 2017 , 37(12) : 3289 -3295 . DOI: 10.6023/cjoc201707024
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