Chinese Journal of Organic Chemistry >
Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group
Received date: 2017-08-10
Revised date: 2017-09-05
Online published: 2017-09-19
Supported by
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640).
In order to find novel pyrazole oxime ethers with good bioactivities, a series of novel pyrazole oxime ether compounds containing substituted pyrazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were characterized by 1H NMR,13C NMR, and elemental analysis. Preliminary bioassay displayed that most target compounds had good insecticidal activities. At the concentration of 500 μg/mL, sixteen compounds showed insecticidal activity against Oriental armyworm with 80%~100%, fourteen compounds exhibited insecticidal activity against Aphis medicaginis with 80%~100%, and twelve compounds showed insecticidal activity against Nilaparvata lugens with 70%~100%. When the dosage was lowered to 100 μg/mL, five compounds still possessed inhibitory effect against Aphis medicaginis with 50%~80%.
Key words： pyrazole; pyrazole oxime; synthesis; bioactivity
Dai Hong , Yao Wei , Sun Siyu , Li Ling , Shi Lei , Qian Hongwei , Li Chunjian , Shi Jian , Shi Yujun . Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group[J]. Chinese Journal of Organic Chemistry, 2017 , 37(12) : 3155 -3162 . DOI: 10.6023/cjoc201708020
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