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Chinese Journal of Organic Chemistry >

2018 , Vol. 38 >Issue 1: 95 - 102

DOI: https://doi.org/10.6023/cjoc201710029

Articles

Efficient Pd-Catalyzed Direct C-H Bond Arylation of Imidazo-[1, 2-a]pyridines with Aryl Chlorides in Aqueous Medium

  • Mu Bing ,
  • Li Jingya ,
  • Zou Dapeng ,
  • Wu Yusheng ,
  • Chang Junbiao ,
  • Wu Yangjie
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  • a School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001;
    b College of Chemistry and Chemical Engineering, Zhengzhou Normal University, Zhengzhou 450044;
    c College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001;
    d Tetranov Biopharm, LLC, Zhengzhou 450001

Received date: 2017-10-24

  Revised date: 2017-11-27

  Online published: 2017-11-28

Supported by

Project supported by the National Natural Science Foundation of China (No. 21702191), the Scientific and Technological Project of Henan Province (No. 172102210555) and the Postdoctoral Science Foundation of Henan Province (No. 2014003).

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Abstract

An efficient and practical protocol for palladium-catalyzed direct C—H bond arylation of imidazo[1,2-a]pyridines with cheap aryl/heteroaryl chlorides has been developed. Various imidazo[1,2-a]pyridines with electron-neutral, electron-poor, electron-rich, even sterically hindered aryl chlorides and heteroaryl chlorides were successfully applied to the reaction in aqueous medium to achieve the 3-arylimidazo[1,2-a]pyridines in mostly good to excellent yields, thus representing a signi?- cant advancement in the implementation of the direct C—H bond arylation of imidazo[1,2-a]pyridines with aryl chlorides.

Key words： C-H bond arylation; imidazo[1,2-a]pyridines; 3-arylimidazo[1,2-a]pyridines; aryl/heteroaryl chlorides; aqueous medium

Cite this article

Mu Bing , Li Jingya , Zou Dapeng , Wu Yusheng , Chang Junbiao , Wu Yangjie . Efficient Pd-Catalyzed Direct C-H Bond Arylation of Imidazo-[1, 2-a]pyridines with Aryl Chlorides in Aqueous Medium[J]. Chinese Journal of Organic Chemistry, 2018 , 38(1) : 95 -102 . DOI: 10.6023/cjoc201710029

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