Chinese Journal of Organic Chemistry >
Facile Access to β-Ketosulfones via Mn-Mediated Reductive Coupling of α-Bromoketones with Sulfonyl Chlorides
Received date: 2017-10-23
Revised date: 2017-12-01
Online published: 2017-12-08
Supported by
Project supported by the Natural Science Foundation of Jiangsu Province (No. BK20150652), the National Natural Science Foundation of China (No. 21502096), the Fundamental Research Funds for the Central Universities (No. KJQN201629), and "333 High Level Talent Project" of Jiangsu Province.
A mild and highly efficient reductive coupling of α-bromoketones with sulfonyl chlorides is described. Various β-ketosulfones can be obtained under mild conditions in good to excellent yields. This method provides a simple and practical access to β-ketosulfones and is amenable to gram scale with no special precautions to exclude air or moisture.
Key words： β-ketosulfones; α-bromoketones; sulfonyl chlorides; reductive coupling; manganese
Chen Zhen , Guo Kang , Chen Rongshun , Gu Chen , Zhou Huating , Zhu Yingguang . Facile Access to β-Ketosulfones via Mn-Mediated Reductive Coupling of α-Bromoketones with Sulfonyl Chlorides[J]. Chinese Journal of Organic Chemistry, 2018 , 38(4) : 963 -968 . DOI: 10.6023/cjoc201710027
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