Chinese Journal of Organic Chemistry >
Applications of Supramolecular Amphiphilc for the Construction of Drug Delivery Systems
Received date: 2017-11-17
Revised date: 2017-12-04
Online published: 2017-12-08
Supported by
Project supported by the National Natural Science Foundation of China (No. 21572101).
Stimuli-responsive supramolecular drug delivery systems (SDDSs) self-assembled by supra-amphiphiles have received tremendous attentions in cancer therapy due to various advantages of SDDSs, such as enhanced drug bioavailability, prolonged blood circulation and retention time, improved drug stability and so on. The construction of smart supramolecular drug delivery systems based on the different structural characteristics of macrocyclic compounds are reviewed and their recent applications in anti-cancer drug delivery are described. Advantages and drawbacks of the current supramolecular drug delivery systems are also discussed, along with the opportunities and challenges in future.
Key words： supra-amphiphile; macrocycles; nanocarrier; drug delivery system
Shao Wei , Liu Xin , Wang Tingting , Hu Xiao-Yu . Applications of Supramolecular Amphiphilc for the Construction of Drug Delivery Systems[J]. Chinese Journal of Organic Chemistry, 2018 , 38(5) : 1107 -1118 . DOI: 10.6023/cjoc201711027
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