Chinese Journal of Organic Chemistry >
Continuous Flow Reaction of Diazo Compounds
Received date: 2017-12-20
Revised date: 2018-01-22
Online published: 2018-02-06
Supported by
Project supported by the National Natural Science Foundation of China (No. 21332002) and the National Basic Research Program of China (973 Program, No. 2015CB856600).
Diazo compounds are versatile building blocks in organic synthesis. They are served as 1,3-dipoles, nucleophiles and carbene precursors in the construction of various organic molecules. However, the utility of diazo compounds is significantly limited by toxicity, instability and explosive potential. The application of continuous flow technology in this field could ensure the safety of these reactions. It also provides the possibility to utilize diazo compounds in a large scale. Categorized by the types of diazo compounds, the application of continuous flow technology in transformations of diazo compounds is systematically reviewed in this paper.
Key words： diazo compound; flow chemistry; microreactor; organic synthesis
Gao Yunpeng , Wang Jianbo . Continuous Flow Reaction of Diazo Compounds[J]. Chinese Journal of Organic Chemistry, 2018 , 38(6) : 1275 -1291 . DOI: 10.6023/cjoc201712029
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