Chinese Journal of Organic Chemistry >
Synthesis and Herbicidal Activity of Novel Cyanoacrylate Derivatives Containing Substituted Oxazole Moiety
Received date: 2018-02-26
Revised date: 2018-03-09
Online published: 2018-03-16
Supported by
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), the Science and Technology Project Fund of Nantong City (No. MS22015020), and the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201710304048).
In search of novel cyanoacrylates with potent bioactivity, a series of new cyanoacrylate derivatives containing substituted oxazole moiety were designed and synthesized through the strategy of active substructure combination. They were structurally characterized by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data showed that most title compounds possessed good herbicidal activity at the dosage of 1500 g/ha, 9 compounds exhibited herbicidal activity against Brassica juncea with 80%~100%, 12 compounds had herbicidal activity against Chenopodium serotinum L. with 80%~100%, two compounds both displayed 70% herbicidal activity against Alopecurus aequalis Sobol, and one compound showed 100%, 70%, and 60% herbicidal activity against Rumex acetosa L., Polypogon fugax Nees ex Steud and Poa acroleuca Steud, respectively. Additionally, the inhibitory rates of one compound against Brassica juncea and Rumex acetosa L.were both 30% at 37.5 g/ha.
Key words： oxazole; cyanoacrylate; synthesis; herbicidal activity
Shi Yujun , Du Xianchao , Wang Xianglong , Chen Qingwen , Li Ling , Dai Hong , Xu Caiqin , Zhang Jingyuan , Ling Yong . Synthesis and Herbicidal Activity of Novel Cyanoacrylate Derivatives Containing Substituted Oxazole Moiety[J]. Chinese Journal of Organic Chemistry, 2018 , 38(7) : 1772 -1778 . DOI: 10.6023/cjoc201802026
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